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Generation and repair of AID-initiated DNA lesions in B lymphocytes
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 201-216 doi: 10.1007/s11684-014-0324-4
Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions.
关键词: class switch recombination somatic hypermutation activation-induced deaminase DNA repair genomic instability
Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic
Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai
《医学前沿(英文)》 2021年 第15卷 第4期 页码 594-607 doi: 10.1007/s11684-020-0809-2
关键词: Psoraleae Fructus bavachin idiosyncratic drug-induced liver injury caspase-1 IL-1β NLRP3 inflammasome
Phase separation time/temperature dependence of thermoplastics-modified thermosetting systems
ZHANG Xiujuan, XU Yuanze, YI Xiaosu
《化学科学与工程前沿(英文)》 2008年 第2卷 第3期 页码 276-285 doi: 10.1007/s11705-008-0057-5
关键词: separation time-temperature temperature dependency cure-induced separation activation temperature
Enhanced activation of peroxymonosulfate by CNT-TiO
Xuemin Hao, Guanlong Wang, Shuo Chen, Hongtao Yu, Xie Quan
《环境科学与工程前沿(英文)》 2019年 第13卷 第5期 doi: 10.1007/s11783-019-1161-0
关键词: Peroxymonosulfate activation Carbon nanotubes TiO2 Water treatment
《化学科学与工程前沿(英文)》 2023年 第17卷 第4期 页码 387-394 doi: 10.1007/s11705-022-2250-3
关键词: self-activation zinc organic salts abundant mesopores symmetric supercapacitor liquid electrolyte
《能源前沿(英文)》 2023年 第17卷 第4期 页码 545-554 doi: 10.1007/s11708-023-0867-7
《化学科学与工程前沿(英文)》 2022年 第16卷 第10期 页码 1485-1492 doi: 10.1007/s11705-022-2169-8
关键词: CH4 dissociation Ni–M C–H bond activation charge transfer
Optimal dynamic emergency reserve activation using spinning, hydro and demand-side reserves
S. Surender REDDY,P. R. BIJWE,A. R. ABHYANKAR
《能源前沿(英文)》 2016年 第10卷 第4期 页码 409-423 doi: 10.1007/s11708-016-0431-9
关键词: demand-side reserves dynamic reserve activation approach hydro power units post contingency sequential reserve activation approach spinning reserves
Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of
《医学前沿(英文)》 doi: 10.1007/s11684-023-1010-1
关键词: exosomes induce activation impair function CD19 exosomal CD19 antigen
Coronary leukocyte activation in relation to progression of coronary artery disease
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 85-90 doi: 10.1007/s11684-016-0435-1
Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two-vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.
关键词: coronary artery disease inflammation integrin myeloperoxidase leukocyte activation
NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway
《医学前沿(英文)》 2023年 第17卷 第2期 页码 263-274 doi: 10.1007/s11684-022-0935-0
关键词: melanoma neuropilin and tolloid-like 2 Ca2+/CaMKII signaling pathway
《环境科学与工程前沿(英文)》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1706-0
● A CNT filter enabled effective KMnO4 activation via facilitated electron transfer.
关键词: KMnO4 Carbon nanotubes Non-radical pathway Electron transfer Water treatment
The role of manganese oxides in the activation of peroxymonosulfate (PMS)
Jianzhi Huang, Huichun Zhang
《环境科学与工程前沿(英文)》 2019年 第13卷 第5期 doi: 10.1007/s11783-019-1158-8
Mohit Nahata, Chang Y. Seo, Pradeep Krishnakumar, Johannes Schwank
《化学科学与工程前沿(英文)》 2018年 第12卷 第1期 页码 194-208 doi: 10.1007/s11705-017-1647-x
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1581-1592 doi: 10.1007/s11705-023-2327-7
关键词: Cu–Al bimetallic oxides mesoporous silica spheres peroxydisulfate bisphenol A
标题 作者 时间 类型 操作
Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic
Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai
期刊论文
Phase separation time/temperature dependence of thermoplastics-modified thermosetting systems
ZHANG Xiujuan, XU Yuanze, YI Xiaosu
期刊论文
Enhanced activation of peroxymonosulfate by CNT-TiO
Xuemin Hao, Guanlong Wang, Shuo Chen, Hongtao Yu, Xie Quan
期刊论文
Hierarchical porous carbon derived from one-step self-activation of zinc gluconate for symmetric supercapacitors
期刊论文
Enhanced performance of oxygen vacancies on CO adsorption and activation over different phases of ZrO
期刊论文
A density functional theory study of methane activation on MgO supported NiM cluster: role of M on C–Hactivation
期刊论文
Optimal dynamic emergency reserve activation using spinning, hydro and demand-side reserves
S. Surender REDDY,P. R. BIJWE,A. R. ABHYANKAR
期刊论文
Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of
期刊论文
Insights into the electron transfer mechanisms of permanganate activation by carbon nanotube membrane
期刊论文
The role of manganese oxides in the activation of peroxymonosulfate (PMS)
Jianzhi Huang, Huichun Zhang
期刊论文
to water purification for resource-constrained settings: Production of activated biochar by chemical activation
Mohit Nahata, Chang Y. Seo, Pradeep Krishnakumar, Johannes Schwank
期刊论文